en Midwifery Orginal research <div style="text-align: justify;"><span style="line-height:2;"><span style="font-size:14px;"><span style="font-family:Times New Roman;"><span style="color:#2980b9;"><b>Background:</b></span> Human papillomavirus (HPV) infection and other sexually transmitted diseases (STDs) remain major public health concerns, particularly among young adults. Midwifery students, as future healthcare professionals, play a key role in prevention, patient education, and counseling. <span style="font-family:"Times New Roman","serif""></span><br> <span style="color:#2980b9;"><b>Objective:</b> </span>This study aimed to assess the level of knowledge about HPV and STD prevention behaviors among midwifery students and their relationship with demographic factors.<br> <b><span style="color:#2980b9;">Methods:</span> </b>This cross-sectional study was conducted on 327 midwifery students (1st to 4th year)<b> </b>of the Department of Midwifery, Faculty of Health Sciences, Karabuk University, T&uuml;rkiye from January to March 2024. Data were collected using a sociodemographic questionnaire, the HPV Knowledge Scale (0-33), and the Scale of Behaviors for Protection from Sexually Transmitted Diseases (STD-SCS; 21&ndash;105). Data were analyzed in R <span lang="EN-GB">software </span>using independent-samples t-tests, ANOVA, Pearson correlation, and multiple linear regression.<span style="font-family:"Times New Roman","serif""></span><br> <span style="vertical-align:baseline"><b><span style="color:#2980b9;">Results:</span> </b><span style="background:white"><span style="color:#0f1115">The mean (SD) HPV knowledge and STD prevention scores were 14.40 (6.73) and 80.42 (9.03), respectively. Students with prior STD/HPV information had significantly higher scores on both measures than those without (<em>p </em>< 0.001). HPV knowledge differed by grade level (F = 15.82,<em> p</em> < 0.001), but prevention scores did not (F = 2.18, <em>p </em>= 0.090). A moderate positive correlation was found between knowledge and prevention scores (r = 0.43,<em> p</em> < 0.001), and knowledge significantly predicted prevention behaviors in regression analysis (&beta; = 0.44, <em>p </em>< 0.0001).</span></span><span style="font-family:"Times New Roman","serif""></span></span><br> <b><span style="color:#2980b9;">Conclusions:</span> </b>Higher HPV knowledge was associated with better preventive behaviors among midwifery students<span lang="EN-GB">. Although HPV knowledge increased with academic grade, preventive behaviours did not. These findings highlight the need for stronger, structured HPV education within midwifery curricula. </span></span></span></span><br> <br> &nbsp;</div> Health education, Human papillomavirus, Midwifery students, Prevention behaviors, Sexually transmitted diseases 4 14 http://nmcjournal.zums.ac.ir/browse.php?a_code=A-10-1050-1&slc_lang=en&sid=1 Elnaz Karamelikli elnazkaramelikli@karabuk.edu.tr 100319475328460014675 100319475328460014675 Yes Department of Midwifery, Faculty of Health Sciences, Karabuk University, Karabuk, Turkey Ayse Cuvadar aysecuvadar@karabuk.edu.tr 100319475328460014676 100319475328460014676 No Department of Midwifery, Faculty of Health Sciences, Karabuk University, Karabuk, Turkey Bilgenur Bulut bilgenurbulut.74@gmail.com 100319475328460014677 100319475328460014677 No Department of Midwifery, Faculty of Health Sciences, Karabuk University, Karabuk, Turkey Seyma Nur Yilmaz seymanur20571@gmail.com 100319475328460014678 100319475328460014678 No Department of Midwifery, Faculty of Health Sciences, Karabuk University, Karabuk, Turkey