en Nursing Orginal research <div style="text-align: justify;"><span style="line-height:2;"><span style="font-family:Times New Roman;"><span style="font-size:14px;"><span style="color:#2980b9;"><b>Background:</b></span> Nurses working in critical care and emergency settings are exposed to substantial occupational and psychological stressors that may adversely affect their mental health. Spiritual well-being and hope are considered important protective factors.<br> <span style="color:#2980b9;"><b>Aim:</b></span> This study aimed to investigate the relationship between spiritual well-being, hope, and positive mental health among nurses working in coronary care units (CCUs), intensive care units (ICUs), and emergency departments (EDs) of teaching hospitals in Zanjan, Iran.<br> <span style="color:#2980b9;"><b>Methods:</b></span> This cross-sectional correlational study included 300 nurses recruited through convenience sampling from CCUs, SICUs, MICUs, and EDs. Data were collected using standardized questionnaires assessing spiritual well-being, hope, and positive mental health and analyzed using Pearson and partial correlation coefficients and multiple linear regression.<br> <span style="color:#2980b9;"><b>Results:</b></span> Participants had a mean age of 32.05 &plusmn; 6.23 years and a mean work experience of 8.34 &plusmn; 5.92 years. Spiritual well-being was positively associated with positive mental health after controlling for hope (r = 0.178, <i>p</i> = 0.002). Hope also remained significantly associated with positive mental health after controlling for spiritual well-being (r = 0.50, <i>p</i> = 0.001). In the final regression model, religious well-being and hope were significant predictors, explaining 29% of the variance in positive mental health.<br> <span style="color:#2980b9;"><b>Conclusion:</b></span> Spiritual well-being and hope were significantly associated with positive mental health among nurses. Strengthening these factors may enhance nurses&#39; well-being and improve the quality of patient care.</span></span></span><br> &nbsp;</div> Spiritual well-being, Hope, Positive mental health, Nurses, Critical care, Emergency departments. 0 0 http://nmcjournal.zums.ac.ir/browse.php?a_code=A-10-1053-2&slc_lang=en&sid=1 Mahtab Aligholipour aligholipourmahtab@gmail.com https://orcid.org/0000-0001-8150-2712 No PhD candidate in nursing, Department of Critical Care and Emergency Nursing, School of Nursing and Midwifery, Zanjan University of Medical Sciences, Zanjan, Iran. Mohammad Hossein Khani MohammadhosseinKhani@gmail.com No MScN, Department of Critical Care and Emergency Nursing, School of Nursing and Midwifery, Zanjan University of Medical Sciences, Zanjan, Iran. Zahra Khezerlou zahrakhezerloo8@gmail.com https://orcid.org/0000-0002-8893-5251 No PhD candidate in nursing, Department of Medical Surgical Nursing, School of Nursing and Midwifery, Zanjan University of Medical Sciences, Zanjan, Iran. Nasrin Hanifi nasrinhanifi@gmail.com https://orcid.org/0000-0002-4027-2399 Yes Associate Professor, Department of Critical Care and Emergency Nursing, School of Nursing and Midwifery, Zanjan University of Medical Sciences, Zanjan, Iran. Parvin Shiri Parvinshiri@gmail.com No Associate Professor, Department of Critical Care and Emergency Nursing, School of Nursing and Midwifery, Zanjan University of Medical Sciences, Zanjan, Iran.