en other Orginal research <strong><em>Background:</em></strong> Although clinical guidelines help in the prevention, diagnosis, and management of hypertension, individuals with hypertension often remain undiagnosed, or once diagnosed, may not receive adequate care and treatment.<br> <strong><em>Objectives: </em></strong>In this study, we explored physicians&rsquo; perspectives of the factors influential in implementing the Iranian Recommendations on Prevention, Evaluation, and Management of Hypertension (IRPEM-HTN).<br> <strong><em>Methods:</em></strong> A qualitative descriptive study was conducted using the purposeful sampling method to enroll 30 physicians from October 2016 to May 2018. The physicians working in private offices or university-affiliated health centers/hospitals in the province of Isfahan, Iran, were included in this study one year after participating in the IRPEM-HTN program. The data were gathered through semi-structured interv iews. The transcribed data were thematically analyzed, and the rigor was ensured following the procedure outlined by Braun and Clark.<br> <strong><em>Results</em>:</strong>This themes identified were: 1) macro- and meso-contextual factors, emphasizing that a) policies at all levels affect guideline adherence, and b) environmental-contextual factors affect guideline adherence, 2) micro level factors, emphasizing that c) attributes of the guideline affect guideline adherence, and d) clinician- and patient-level factors affect guideline adherence. Micro-, meso- and macro-level factors influenced guideline implementation.<br> <strong><em>Conclusion:</em></strong> The attitudes, awareness, knowledge, and capacity of clinicians, as well as a broader socio-cultural context should be taken into account for guideline implementation. hypertension, preventive care, clinical practice guideline, facilitators, barriers, physicians 55 62 http://nmcjournal.zums.ac.ir/browse.php?a_code=A-10-791-1&slc_lang=en&sid=1 Alireza Khosravi alikh108@yahoo.com 10031947532846008407 10031947532846008407 No professor, hypertension research center, Isfahan cardiovascular research institute, Isfahan university of medical sciences,Isfahan,Iran Mousa Alavi m_alavi@nm.mui.ac.ir 10031947532846008408 10031947532846008408 Yes Ph.D, Associate Professor, Nursing and Midwifery Care Research Center, Isfahan university of Medical Sciences, Isfahan, Iran Maryam Eghbali Babadi eghbali@nm.mui.ac.ir 10031947532846008409 10031947532846008409 No PhD, Assistant Professor, Nursing and Midwifery Care Research Center, Isfahan University of Medical Sciences, Isfahan, Iran Mohsen Shahriari shahriari@nm.mui.ac.ir 10031947532846008410 10031947532846008410 No Ph.D, Professor, Nursing and Midwifery Care Research Center, Adult Health Nursing Department, Faculty of Nursing and Midwifery, Isfahan University of Medical Sciences, Isfahan, Iran Razieh Molavi raziehMolavi@yahoo.com 10031947532846008411 10031947532846008411 No MSc of Elderly Nursing, Al-Zahra Hospital, Isfahan University of Medical Sciences, Isfahan, Iran Azam Mahmoodi a.mahmoodi@dehaghan.ac.ir 10031947532846008412 10031947532846008412 No BScN, MScN, Faculty Member of Nursing Department, Islamic Azad University Dehaghan Branch, Dehaghan, Isfahan, Iran Mandy Archibald mandy.archibald@umanitoba.ca 10031947532846008413 10031947532846008413 No BScN, PhD, University of Manitoba, College of Nursing, Rady Faculty of Health Sciences, 99 Curry Pl, Helen Glass Centre for Nursing, Winnipeg, Manitoba