en Nursing Orginal research <span style="line-height:2;"><span style="font-size:14px;"><span style="font-family:Times New Roman;"><span style="unicode-bidi:embed"><span sans-serif=""><span style="color:#2980b9;"><b><i><span new="" roman="" times="">Background:</span></i></b></span><span style="color:#000066;"> </span><span new="" roman="" times="">One of the main steps for designing a comprehensive palliative care program in patients with cancer is to achieve knowledge about pain acceptance</span><span new="" roman="" times="">. </span></span></span><br> <span style="unicode-bidi:embed"><span sans-serif=""><b><i><span new="" roman="" times=""><span style="color:#2980b9;">Objectives:</span> </span></i></b><span new="" roman="" times="">This study aims to determine the level of pain acceptance and its related social determinants of health in patients with cancer</span><span new="" roman="" times="">.</span></span></span><br> <span new="" roman="" times=""><span style="color:#2980b9;"><b><i>Methods:</i></b> </span><span style="color:black">This cross-sectional study conducted on 152 patients with cancer hospitalized in the oncology wards of Valiasr and Ayatollah Mousavi hospitals in Zanjan. Participants were included in the study by convenience sampling from June to September 2021. To collect the data, a three-part questionnaire including demographic factors, social determinants and chronic pain acceptance was utilized. Statistical analysis was performed by t-test and one-way analysis of variance (ANOVA) using SPSS software version 25.</span></span><br> <span style="unicode-bidi:embed"><span sans-serif=""><span style="color:#2980b9;"><b><i><span new="" roman="" times="">Results</span></i><span new="" roman="" times="">:</span></b></span> <span new="" roman="" times="">Most of the participants were male (52%), illiterate (56.6%) and in the age group of 61-75 years (40.1%)</span><b><span new="" roman="" times="">.</span></b> <span new="" roman="" times="">The mean (SD) of the total pain acceptance score was 53.37 (19.36), which represents a lower than mean pain acceptance among the participants. The mean of pain acceptance according to the two variables of transportation system (P< 0.001) and occupation (P= 0.003) showed a statistically significant difference</span><span new="" roman="" times="">.</span></span></span><br> <span style="unicode-bidi:embed"><span sans-serif=""><span style="color:#2980b9;"><b><i><span new="" roman="" times="">Conclusion:</span></i></b></span><span new="" roman="" times=""><span style="color:#2980b9;"> </span>The findings of the study indicate that pain acceptance in the participants is not desirable. It is essential to plan and put into effects programs in order to improve pain acceptance methods. Moreover, considering the relationship between social determinants of health and pain acceptance, it requires to pay more attention to social determinants of health during the development of interventions to improve patients&rsquo; pain acceptance.</span></span></span><br> &nbsp;</span></span></span> Pain Acceptance, Cancer-Related Pain, Social Determinants of Health 50 58 http://nmcjournal.zums.ac.ir/browse.php?a_code=A-10-852-2&slc_lang=en&sid=1 Mahsa Nouri mahsa.noori1375@gmail.com 100319475328460013925 100319475328460013925 No Department of Medical Surgical Nursing, Zanjan Nursing and Midwifery School, Zanjan University of Medical Sciences, Zanjan, Iran Nasrin Bahrami Nejad bahrami_n@zums.ac.ir 100319475328460013926 100319475328460013926 Yes Social Determinants of Health Research Center, Zanjan University of Medical Sciences, Zanjan, Iran Masoumeh Namadian m.namadian@zums.ac.ir 100319475328460013927 100319475328460013927 No Social Determinants of Health Research Center, Zanjan University of Medical Sciences, Zanjan, Iran Elham Faghihzadeh e.faghihzadeh@zums.ac.ir 100319475328460013928 100319475328460013928 No Department of Epidemiology and Biostatistics, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran