en Midwifery Review Articels <div style="text-align: justify;"><span style="font-size:14px;"><span style="font-family:Times New Roman;"><span style="line-height:2;"><span style="unicode-bidi:embed"><span style="color:#2980b9;"><b><span new="" roman="" times="">Background</span></b></span><b><span new="" roman="" times=""><span style="color:#2980b9;">:</span><span style="color:black"> </span></span></b><span new="" roman="" times=""><span style="color:black">Pain and infection after episiotomy are common challenges that hinder maternal recovery. Curcumin, with anti-inflammatory and antimicrobial properties, is a potential therapeutic agent, but its efficacy for episiotomy healing is unproven. </span></span></span><br> <span style="unicode-bidi:embed"><span style="color:#2980b9;"><b><span new="" roman="" times="">Objectives</span></b></span><span new="" roman="" times=""><span style="color:#2980b9;">:</span><span style="color:black"> This study aimed to systematically evaluate the effect of topical curcumin on episiotomy wound healing.</span></span></span><br> <span style="unicode-bidi:embed"><span style="color:#2980b9;"><b><span new="" roman="" times="">Methods</span></b></span><b><span new="" roman="" times=""><span style="color:#2980b9;">:</span><span style="color:black"> </span></span></b><span new="" roman="" times=""><span style="color:black">Databases including Google Scholar, PubMed, Cochrane, Web of Sciences, Scopus, Embase, ProQuest, SID, and Magiran were searched until March 11, 2025, using MeSH and Emtree keywords. Risk of bias was assessed with Cochrane RoB 1 and ROBINS-I tools. A random-effects meta-analysis calculated the mean difference (MD) with 95% CIs. Heterogeneity was quantified by the I&sup2; statistic, and evidence certainty was assessed using the GRADE framework.</span></span></span><br> <span style="unicode-bidi:embed"><span style="color:#2980b9;"><b><span new="" roman="" times="">Results</span></b><b><span new="" roman="" times="">:</span></b></span><span new="" roman="" times=""><span style="color:black"> The search retrieved 2531 articles; after removing duplicates and ineligible studies, four articles were included in the systematic review. Meta-analysis of three studies showed no statistically significant effect of curcumin on perineal wound healing compared to controls (MD = -1.02; 95% CI: -2.39 to 0.35, P = 0.14), with substantial heterogeneity (I&sup2; = 83%, p = 0.003). Evidence quality was very low.</span></span></span><br> <span style="color:#2980b9;"><b><span new="" roman="" times="">Conclusion:</span></b></span><span new="" roman="" times=""><span style="color:black"> Based on a limited number of studies, available evidence is of very low quality and does not demonstrate a statistically significant effect of curcumin on episiotomy wound healing. Due to the scarcity and low quality of evidence, firm conclusions cannot be drawn. This review underscores a critical evidence gap, highlighting the urgent need for high-quality randomized </span></span></span></span></span></div> Episiotomy, Curcumin, Wound Healing 72 83 http://nmcjournal.zums.ac.ir/browse.php?a_code=A-10-1040-1&slc_lang=en&sid=1 Fatemeh Shabani fatemehshabani7697@gmail.com 100319475328460014435 100319475328460014435 No Midwifery Department, Faculty of Nursing and Midwifery, Tabriz University of Medical Sciences, Tabriz, Iran. Mojgan mirghafourvand mirghafourvand@gmail.com 100319475328460014436 100319475328460014436 No Social Determinants of Health Research Center, Faculty of Nursing and Midwifery, Tabriz University of Medical Sciences, Tabriz, Iran Maryam Montazeri maryammontazeri5053@yahoo.com 100319475328460014437 100319475328460014437 No faculty of Nursing and midwifery, khalkhal branch, Islamic Azad university, khalkhal, Iran Robab Hasanzadeh hasanzadehr@iau.ac.ir 100319475328460014438 100319475328460014438 Yes Department of Nursing and Midwifery, Bon.C., Islamic Azad University, Bonab, Iran.