en Investigating the Relationship between hs-CRP Serum Level and Insulin Resistance (HOMA IR) Six Weeks after Childbirth in Patients with Gestational Diabetes Mellitus Midwifery Orginal research <p><strong><em>Background:</em></strong> Some patients with GDM (Gestational Diabetes Mellitus) still experience impaired glucose tolerance after childbirth and will be affected by diabetes mellitus type 2.</p> <p><strong><em>Objectives: </em></strong>The aim of this study is to investigate the relationship between hs-CRP serum levels with insulin resistance six weeks after childbirth in patients with gestational diabetes mellitus type 2.</p> <p><strong><em>Methods:</em></strong> In this descriptive cross-sectional study, 110 patients with GDM were evaluated in terms of the insulin resistance index (HOMA), hs-CRP serum, and the oral glucose tolerance test (OGTT) six weeks after childbirth. Their anthropometric indices were measured in the early pregnancy. Spearman&rsquo;s rank correlation coefficient and linear regression analysis were used to analyze data in SPSS 16.</p> <p><strong><em>Results</em></strong><strong>:</strong> The mean of hs-CRP was 8.72 &micro;g/ml among the patients in this study. It is higher than the normal range. Moreover, 24.5% of the patients were suffering from impaired glucose tolerance, and hs-CRP levels were higher than the normal range in 92.6% of these patients. Furthermore, 41.8% of patients showed insulin resistance, and hs-CRP levels were high among 73.9% of them. After age adjustment, the increase in hs-CRP serum level was significantly correlated with insulin resistance (HOMA) and the one-hour and two-hour OGTTs (p=0.007 and p<0.001, respectively).</p> <p><strong><em>Conclusion:</em></strong> It appears that age adjustment can help us figure out the relationship between the increase in hs-CRP serum and insulin resistance in pregnant mothers with diabetes six weeks after childbirth.</p> <p></p> Hs-CRP serum level, Insulin resistance, Postpartum, GDM (Gestational Diabetes Mellitus) 47 54 http://nmcjournal.zums.ac.ir/browse.php?a_code=A-10-536-1&slc_lang=en&sid=1 Shirin Mozayyan sh.mozayyan@gmail.com 10031947532846007810 10031947532846007810 No MSc. Dept. of Biology, Biochemistry, Payame noor University of Medical Sciences, Isfahan, Iran Ali Mellati Mellati3000@yahoo.com 10031947532846007811 10031947532846007811 Yes PhD. Dept. of Biochemistry & Metabolic research center, Professor, Zanjan University of Medical Sciences, Zanjan, Iran Habib Nazem 10031947532846007812 10031947532846007812 No PhD. Dept. of Biology, Biochemistry, Payame noor University of Medical Sciences, Isfahan, Iran Hosein Salavati 10031947532846007813 10031947532846007813 No PhD. Dept. of chemistry, Associate Professor, Payame noor University of Medical Sciences, Tehran, Iran Hosein Chiti 10031947532846007814 10031947532846007814 No Endocrinologyst, Metabolic research center, Assistant Professor, Zanjan University of Medical Sciences, Zanjan, Iran