en other Orginal research <strong><em>Background:</em></strong> Thalassemia is one of the main chronic hereditary diseases characterized by severe symptoms of anemia. Also, it has negative effects on patients&rsquo; mental health. However, few researches have studied the different psychiatric aspects of this disease and the psychological and social needs of thalassemic patients.<br> <strong><em>Objectives: </em></strong>The aim of the present study was to investigate the effect of stress management and resilience training on psychological well-being of thalassemic patients in Kerman.<br> <strong><em>Methods:</em></strong> This research was a quasi-experimental study using pre-test and post-test model with control group. A sample of 30 patients with thalassemia major, who referred to the Samen al-Hojaj Charity Foundation, was selected through convenience sampling and randomly divided into experimental and control groups (each group included 15 patients). After completing the pre-test, the experimental group received 10 sessions of stress management training. The instrument of the study was Reef Psychological Well-being Questionnaire (RPWB). Data were analyzed by SPSS software using covariance analysis.<br> <strong><em>Results</em></strong><strong>:</strong> The results indicated that resilience and stress management training have positive effects on psychological well-being and its subscales including self-acceptance, positive relationship with others, autonomy, personal development and purposeful life of thalassemia major patients (p<0.05), yet it is not effective on environmental control (<a name="_Hlk30861780">p>0.05</a>).<br> <strong><em>Conclusion:</em></strong> According to the results, regarding the effectiveness of resilience and stress management on the psychological well-being of thalassemic patients, the present study could introduce effective solution for development of psychological well-being and improvement of overall mental health of patients with thalassemia major. resilience, stress management, psychological well-being, thalassemia major 8 15 http://nmcjournal.zums.ac.ir/browse.php?a_code=A-10-575-3&slc_lang=en&sid=1 Mohammad Reza Babaei mrb2549@gmail.com 10031947532846007512 10031947532846007512 No MSc. Dept. of Psychology, Shahid Bahonar University, Kerman, Iran Gasem Askarizadeh gh.askarizadeh@uk.ac.ir 10031947532846007513 10031947532846007513 Yes PhD. Dept. of Psychology, Associate Professor, Shahid Bahonar University, Kerman, Iran Afsaneh Towhidi atowhidi@mail.uk.ac.ir 10031947532846007514 10031947532846007514 No PhD. Dept. of Psychology, Associate Professor, Shahid Bahonar University, Kerman, Iran