en other Orginal research <strong><em>Background:</em></strong> Sexual dysfunction is one of the factors causing adverse effects on marital life.<br> <strong><em>Objectives: </em></strong>Therefore, the present study aimed at predicting female sexual function based on circadian rhythms and anxiety sensitivity.<br> <strong><em>Methods:</em></strong> The present descriptive-correlational study was performed on 378 married women referring to cultural centers in Isfahan, Iran, from September 2019 to March 2020. The multistage cluster and then convenience sampling methods were used to select samples. Data collection instruments included the female sexual function index developed by Rosen et al., morningness-eveningness personality questionnaire designed by Horne and Ostberg, and anxiety sensitivity index developed by Floyd et al. The collected data were analyzed using Pearson correlation coefficient and stepwise regression with SPSS version 24.<br> <strong><em>Results</em>::</strong> The means of age and marriage years of the study participants were 32.53&plusmn;7.74 and 7.09&plusmn;3.76 years, respectively. The mean score of their sexual function was 56.85&plusmn;12.65 and the circadian rhythm 40.84&plusmn;11.57, and the overall score of anxiety sensitivity 44.99&plusmn;7.19. The findings also showed that the relationship between sexual function and circadian rhythms was 0.17 and anxiety sensitivity -0.18 (P<0.01). The relationship between sexual function and the components of anxiety-related physical sensations, cognitive dyscontrol, and fear of publicly observable anxiety was -0.14, -0.13, and -0.11, respectively (P<0.05). In the first stage, anxiety sensitivity could predict 16.7% of changes in sexual function and circadian rhythms 7.1% of the mean changes in sexual function (P<0.001), so it can be said that anxiety sensitivity and morningness personality could predict 24% of sexual dysfunction variation (P<0.001).<strong><em>Conclusion:</em></strong> The present study findings show that anxiety sensitivity and circadian rhythms are among the factors affecting sexual function; therefore, it is recommended to reduce anxiety and improve sleep quality to treat sexual disorders in married women. sexual dysfunction, circadian rhythms, anxiety sensitivity 20 27 http://nmcjournal.zums.ac.ir/browse.php?a_code=A-10-732-2&slc_lang=en&sid=1 Ameneh Dashtestannejad a.dashtestan1983@gmail.com 10031947532846007262 10031947532846007262 No PhD Student in General Psychology, Department of Psychology, Najafabad Branch, Islamic Azad University, Najafabad, Iran Akram Dehghani Ddehghani55@yahoo.com 10031947532846007263 10031947532846007263 Yes Assistant Professor, Department of Psychology, Najafabad Branch, Islamic Azad University, Najafabad, Iran. Azam Salehi salehi120@yahoo.com 10031947532846007264 10031947532846007264 No Assistant Professor, Counseling Department, Khorasgan Branch, Payame Noor University, Khorasgan, Iran Mohammad Massoud Dayarian masood.dayarian@gmail.com 10031947532846007265 10031947532846007265 No PhD in Family Counseling, Counseling Department, Khomeini Shahr Branch, Islamic Azad University, Khomeini Shahr, Iran