en Midwifery Orginal research <pre data-placeholder="ترجمه" dir="ltr"> <strong><em>Background:</em></strong> Infertility is a painful emotional experience associated with stress. <strong><em>Objectives: </em></strong>The present study aimed at determining infertility-related stress and its associated factors in infertile clients referred to the infertility clinic of Al-Zahra hospital in Rasht, Iran, in 2019. <strong><em>Methods:</em></strong> The present cross-sectional study was performed on 200 clients undergoing infertility treatment, selected by the convenience sampling method, and completed the Copenhagen multi- centre psychological infertility-fertility problem scales (COMPI-FPSS). Descriptive and inferential statistics (the Kolmogorov-Smirnov, Mann-Whitney, Kruskal-Wallis, Chi-square, and t-tests, as well as the Spearman correlation coefficient, AVONA, and multiple linear regression) were used to analyze the data in SPSS version 16.</pre> <strong><em>Results</em>::</strong> The results showed that the mean total score of infertility stress was 28.67<span dir="RTL">&plusmn;</span>9.85 in the study subjects. The mean scores obtained in personal, marital, and social domains of COMPI-FPSS were 15.29<span dir="RTL">&plusmn;</span>5.39, 7.43<span dir="RTL">&plusmn;</span>3.72, and 5.95<span dir="RTL">&plusmn;</span>2.47, respectively. A significant difference was observed in the stress score between males and females (P<0.001). There was a significant relationship between income adequacy (P=0.005), frequency of unsuccessful infertility treatment (P=0.001), duration of treatment (P=0.009), and infertility-related stress. <pre data-placeholder="ترجمه" dir="ltr"> <strong><em>Conclusion:</em></strong> Infertile subjects experienced more stress in the personal domain compared to other domains. Stress scores were significantly associated with gender, financial status, frequency of unsuccessful infertility treatment, and the duration of treatment variables. Therefore, providing counseling services and psychosocial interventions infertility treatment clinics in order to meet the psychological needs of infertile clients is an undeniable necessity.</pre> infertility, infertile couples, stress, infertility-related stress 1 10 http://nmcjournal.zums.ac.ir/browse.php?a_code=A-10-769-1&slc_lang=en&sid=1 Fatemeh Jafar zadeh-Kenarsari f.kenarsari2013@gmail.com 10031947532846007140 10031947532846007140 No Social Determinants of Health Research Center, Department of Midwifery, School of Nursing and Midwifery, Guilan University of Medical Sciences, Rasht, Iran Ladan Ahmad-Amraji ladanahmadi840@gmail.com 10031947532846007141 10031947532846007141 Yes Department of Midwifery, School of Nursing and Midwifery, Guilan University of Medical Sciences, Rasht, Iran Kobra Abouzari-Gazafroodi kaboozari@yahoo.com 10031947532846007142 10031947532846007142 No Department of Midwifery, Zeynab (P.B.U.H) School of Nursing and Midwifery, Guilan University of Medical Sciences, Rasht, Iran