en Nursing Orginal research <span style="line-height:2;"><span style="font-size:14px;"><span style="font-family:Times New Roman;"><span style="unicode-bidi:embed"><span calibri=""><span style="color:#2980b9;"><b><i><span new="" roman="" times="">Background:</span></i></b></span><span style="color:#000066;"> </span><span new="" roman="" times="">A health-promoting lifestyle and optimal health literacy are among the determining health promotion and maintenance sources. </span></span></span><br> <span style="unicode-bidi:embed"><span calibri=""><span style="color:#2980b9;"><b><i><span new="" roman="" times="">Objectives:</span></i></b><b> </b></span><span new="" roman="" times="">The current study was conducted to determine the status of health-promoting lifestyle and its relationship with health literacy of employees of Zanjan University of Medical Sciences in 2020.</span></span></span><br> <span new="" roman="" times=""><span style="color:#2980b9;"><b><i>Methods:</i></b> </span><span style="color:black">This cross-sectional descriptive-correlational study was conducted on 308 administrative employees of faculties, hospitals, and health centers in Zanjan. The participants were included in the study using a stratified random sampling method. Three questionnaires, including the demographic information questionnaire, the standard Health-Promoting Lifestyle Profile II (HPLPII) questionnaire, and the Health Literacy for Iranian Adults (HELIA) questionnaire, were used to collect data. Data were analyzed using descriptive and inferential statistics (Pearson&rsquo;s correlation and stepwise regression) in SPSS 24.</span></span><br> <span style="unicode-bidi:embed"><span calibri=""><span style="color:#2980b9;"><b><i><span new="" roman="" times="">Results:</span></i></b></span><span new="" roman="" times=""> The mean age of the employees was 36.51(7.29) years, and most of the participants were female (53.2%), married (80.8%), and had a bachelor&rsquo;s degree or higher (89.3%). The participants&rsquo; health literacy score was at an adequate level 75.85 (12.23) and their lifestyle score was at a desirable level 137.22 (21.15). The relationship between health literacy dimensions and the lifestyle total score was positive and significant (p>0.05).</span></span></span><br> <span style="unicode-bidi:embed"><span calibri=""><span style="color:#2980b9;"><b><i><span new="" roman="" times="">Conclusion:</span></i></b></span><span new="" roman="" times=""> According to the findings of the current study and the presence of a relationship between health literacy and lifestyle, particularly the predictive role of decision-making dimensions and accessibility of health literacy with the lifestyle of employees, it is suggested that programs be developed and implemented to empower the health literacy of employees.</span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span style="unicode-bidi:embed"><span calibri="" style="font-family:"><span style="font-size:8.0pt"><span style="font-family:"MyriadPro-Light","serif""></span></span></span></span></span></span> Health-Promoting Lifestyle, Health literacy, Employees, University of Medical Sciences 21 28 http://nmcjournal.zums.ac.ir/browse.php?a_code=A-10-964-1&slc_lang=en&sid=1 Zahra Hajagharezaloo Z.hajagharezaloo@gmail.com 100319475328460013718 0009-0005-4641-1264 No Department of Community Health Nursing, School of Nursing and Midwifery, Zanjan University of Medical Sciences Nasrin Jafari Varjoshani Jafari_ns@zums.ac.ir 100319475328460013719 100319475328460013719 Yes Department of Community Health Nursing, School of Nursing and Midwifery, Zanjan University of Medical Sciences Masoumeh Moqaddam masoumemoqaddam@gmail.com 100319475328460013720 100319475328460013720 No Department of Community Health Nursing, School of Nursing and Midwifery, Zanjan University of Medical Sciences Ramezan Fallah ramazanfallah@yahoo.com 100319475328460013721 100319475328460013721 No Department of Epidemiology and Biostatistics, School of Medicine, Zanjan University of Medical Sciences