en Nursing Orginal research <span style="line-height:2;"><span style="font-size:14px;"><span style="font-family:Times New Roman;"><span style="unicode-bidi:embed"><span calibri=""><span style="color:#2980b9;"><b><i><span new="" roman="" times="">Background:</span></i></b></span> <span new="" roman="" times="">Diabetes is considered one of the most arduous chronic diseases emotionally and behaviorally. This disease is an integral part of the patient&rsquo;s lives, and not paying attention to the psychological stress stemming from it, not only leads to the occurrence of psychological symptoms and frustration, but also influences self-care behaviors, such as blood sugar control, proper use of medicines, and medication regimen adherence. </span></span></span><br> <span style="unicode-bidi:embed"><span calibri=""><b><span new="" roman="" times=""><span style="color:#2980b9;"><em>Objectives:</em></span> </span></b><span new="" roman="" times="">This study was conducted to determine the relationship between psychological stress and medication regimen adherence in patients with type 2 diabetes.</span></span></span><br> <span new="" roman="" times=""><span style="color:#2980b9;"><em><b>Methods:</b></em></span><span style="color:black"> This descriptive-correlational study was conducted on 101 patients referring to diabetes clinics affiliated with Zanjan University of Medical Sciences in 2023. Sampling was carried out using the convenience sampling method. A demographic characteristics questionnaire, the Problems Areas in Diabetes-5 (PAID-5) Scale, and the Mo risky Medication Adherence Scale-8 (MMAS-8) were used to collect data. Data were analyzed using descriptive statistics, the Mann-Whitney U test, the Kruskal-Wallis test, and Spearman&rsquo;s test, with SPSS-26 software.</span></span><br> <span style="unicode-bidi:embed"><span calibri=""><span style="color:#2980b9;"><em><b><span new="" roman="" times="">Results:</span></b></em></span><span style="color:#000066;"> </span><span new="" roman="" times="">In the present research, 68.3% of the participants were female and 31.7% were male. The mean (standard deviation) stress score was 9.579 (7.448). Also, 58.4% of the participants had a stress score of &ge;8, indicating high psychological stress. The mean (standard deviation) of medication adherence was 6.054 (1.874), which based on the findings, 43.6% had a poor adherence score. Spearman&rsquo;s correlation coefficient showed an inverse and significant statistical relationship between psychological stress and medication adherence (p =0.002, r=-0.307).</span></span></span><br> <span style="unicode-bidi:embed"><span calibri=""><span style="color:#2980b9;"><em><b><span new="" roman="" times="">Conclusion:</span></b></em></span> <span new="" roman="" times="">According to the results, the higher the psychological stress of diabetic patients, the lower their medication adherence. It is suggested that targeted interventions should be designed to manage psychological stress and improve medication adherence in diabetic patients.</span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span style="unicode-bidi:embed"><span calibri="" style="font-family:"><span style="font-size:8.0pt"><span style="font-family:"MyriadPro-Light","serif""></span></span></span></span></span></span> Psychological Stress, Medication Adherence,Type 2 Diabetic Patients 1 10 http://nmcjournal.zums.ac.ir/browse.php?a_code=A-10-967-1&slc_lang=en&sid=1 Zeinab Yousefli z.yusefli2016@gmail.com 100319475328460013711 0009-0007-3814-9416 No Department of Medical-Surgical Nursing, School of Nursing and Midwifery, Zanjan University of Medical Sciences, Zanjan, Iran Mojghan Sadat Aghvamy aghvamym@zums.ac.ir 100319475328460013712 100319475328460013712 Yes Department of Medical-Surgical Nursing, School of Nursing and Midwifery, Zanjan University of Medical Sciences, Zanjan, Iran Zeinab Ghahramani ghahremani@zums.ac.ir 100319475328460013713 100319475328460013713 No Department of Psychiatric Nursing, School of Nursing and Midwifery, Zanjan University of Medical Sciences, Zanjan, Iran