en Midwifery Orginal research <div style="text-align: justify;"><span style="line-height:2;"><span style="font-size:14px;"><span style="font-family:Times New Roman;"><span style="color:#2980b9;"><b>Background:</b></span> Infertility poses significant psychosocial challenges for women, profoundly impacting their well-being and quality of life. Infertility stigma and self-efficacy, reflecting a woman&rsquo;s confidence in managing infertility-related challenges, are key factors influencing this experience.<br> <span style="color:#2980b9;"><b>Objectives</b>:</span> This study examined the mediating role of psychological resilience in the associations between infertility stigma, infertility self-efficacy, and fertility-related quality of life (FertiQoL) among infertile women.<br> <span style="color:#2980b9;"><b>Methods:</b></span> A cross-sectional, correlational design was employed, involving 295 infertile women recruited via convenience sampling from fertility clinics in Ahvaz, Iran, in 2024. Data were collected using the Fertility Quality of Life (FertiQoL) scale, Infertility Stigma Scale (ISS), Infertility Self-Efficacy Scale (ISES), and Connor-Davidson Resilience Scale (CD-RISC). Structural Equation Modeling (SEM) was conducted using SPSS and AMOS software to analyze relationships.<br> <span style="color:#2980b9;"><b>Results:</b></span> The model demonstrated a strong fit to the data. Direct paths from infertility stigma and self-efficacy to FertiQoL were non-significant. However, significant direct associations were found between infertility stigma and resilience (&beta;=-0.22, P<0.001), and between self-efficacy and resilience (&beta;=0.24, P<0.001). Psychological resilience significantly mediated the relationships between infertility stigma and FertiQoL (&beta;=-0.06, P=0.001), and between self-efficacy and FertiQoL (&beta;=0.01, P=0.001), indicating its critical role in these pathways. The final structural model exhibited good fit to the data (&chi;&sup2;/df=1.60, CFI=0.94, RMSEA=0.04).<br> <span style="color:#2980b9;"><b>Conclusion:</b></span> Psychological resilience serves as a vital protective factor, mitigating the adverse effects of infertility stigma and enhancing the positive influence of self-efficacy on FertiQoL. These findings underscore the importance of fostering resilience in clinical interventions to improve psychological well-being and quality of life among infertile women.</span></span></span></div> Infertility, Resilience, Stigma, Self-Efficacy, Quality of Life 14 23 http://nmcjournal.zums.ac.ir/browse.php?a_code=A-10-1052-1&slc_lang=en&sid=1 Anahid Behbahani Mondanizadeh baghbanzadehmrm@gmail.com 100319475328460014478 100319475328460014478 No Department of Psychology, Ahv.C., Islamic Azad University, Ahvaz, Iran Rezvan Homaei rzhomaei@gmail.com 100319475328460014479 100319475328460014479 Yes Department of Psychology, Ahv.C., Islamic Azad University, Ahvaz, Iran Fariba Hafezi fhaffezi@gmail.com 100319475328460014480 100319475328460014480 No Department of Psychology, Ahv.C., Islamic Azad University, Ahvaz, Iran Marzieh Talebzadeh Shoushtari talebzademarzieh@gmail.com 100319475328460014481 100319475328460014481 No Department of Psychology, Ahv.C., Islamic Azad University, Ahvaz, Iran