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Volume 15, Issue 2 (10-2025)                   Prev Care Nurs Midwifery J 2025, 15(2): 42-49 | Back to browse issues page

Ethics code: IR.TUMS.FNM.REC.1399.201


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bayat Z, Behboodi Moghadam Z, Haghani S. Effect of inhalation aromatherapy with neroli oil on pain reduction of the primary dysmenorrhea: A clinical trial study. Prev Care Nurs Midwifery J 2025; 15 (2) :42-49
URL: http://nmcjournal.zums.ac.ir/article-1-982-en.html
1MSc, Department of Midwifery, School of Nursing and Midwifery, Tehran University of Medical Sciences, Tehran, Iran , z.bayat1995sb@gmail.com
Abstract:   (297 Views)
Background: Primary dysmenorrhea, characterized by abdominal pain during menstruation resulting from uterine contraction and ischemia, affects approximately 50% of women.  
Objectives: This study aimed to evaluate the effect of inhalation aromatherapy with neroli oil on the pain reduction of dysmenorrhea.
Methods: This two-group randomized clinical trial (non-blinded due to odor) was conducted in 2021 among 70 students of Zanjan University of Medical Sciences with primary dysmenorrhea. Participants were randomly assigned to the neroli oil or placebo group using numbers 1–70 generated at www.graphpad.com. Each was followed over four menstrual cycles: during the first two, pain intensity was recorded using a Visual Analogue Scale (VAS) without treatment; during the next two, inhalation aromatherapy with 2% neroli oil or placebo was applied once daily for 30 minutes on the first two days of menstruation. Data were analyzed in SPSS 26 using repeated measures ANOVA and independent t-tests.
Results: A significant difference in pain severity was observed between the two groups following the intervention, during both the first (t = 3.77, p = .001) and second cycles (t = 4.07, p < .001). In the intervention group, the mean pain intensity (SD) decreased from 6.58 (0.95) and 6.19 (0.98) before the intervention to 2.83 (0.68) and 2.32 (0.79) afterwards. Similarly, in the control group, pain scores reduced from 6.29 (1.18) and 6.16 (1.03) to 3.64 (1.14) and 3.35 (1.17), respectively.
Conclusion:  In conclusion, Neroli oil aromatherapy appears to be effective in reducing the pain intensity associated with primary dysmenorrhea (PD).
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Type of Study: Orginal research | Subject: Midwifery

References
1. 1. Arsyad A, Usman AN, Syamsuddin S, Ahmad M, Sinrang AW. The Use of Aromatherapy in Primary Dysmenorrhea. Gaceta Sanitaria. 2021;35:S591-S595. [https://doi.org/10.1016/j.gaceta.2021.10.090] [PMID]
2. Gutman G, Nunez AT, Fisher M. Dysmenorrhea in Adolescents. Current Problems in Pediatric and Adolescent Health Care. 2022;52(5):101186. [https://doi.org/10.1016/j.cppeds.2022.101186] [PMID]
3. Itani R, Soubra L, Karout S, Rahme D, Karout L, Khojah HM. Primary Dysmenorrhea: Pathophysiology, Diagnosis, and Treatment Updates. Korean Journal of Family Medicine. 2022;43(2):101-108. [https://doi.org/10.4082/kjfm.21.0103] [PMID]
4. Trisnawati Y, Sulistyowati N. Pain Reduction From Dysmenorrhea Using a Warm Compress and Lavender Aromatherapy. International Journal of Public Health Excellence. 2022;2:285-290. [https://doi.org/10.55299/ijphe.v2i1.225]
5. Najaf Najafi M, Hadavi F, Vazirinasab Kermani S, Vafisani F, Ghazanfarpour M. Aromatherapy With Iranian Herbal Medicines for Premenstrual Syndrome and Primary Dysmenorrhea: A Systematic Review and Meta-Analysis. Journal of Pediatric Perspectives. 2019;7(9):10155-10166. [https://doi.org/10.22038/ijp.2019.42455.3563]
6. Samani RO, Hashiani AA, Razavi M, Vesali S, Rezaeinejad M, Maroufizadeh S, et al. The Prevalence of Menstrual Disorders in Iran: A Systematic Review and Meta-Analysis. International Journal of Women's Health and Reproduction Sciences. [Publication details incomplete in source]. [https://pmc.ncbi.nlm.nih.gov/articles/PMC635l]
7. Sun L, Liu LN, Li JC, Lv YZ, Zong SB, Zhou J, et al. The Essential Oil From the Twigs of Cinnamomum Cassia Presl Inhibits Oxytocin-Induced Uterine Contraction in Vitro and in Vivo. Journal of Ethnopharmacology. 2017;206:107-114. [https://doi.org/10.1016/j.jep.2017.05.023] [PMID]
8. Niazi A, Moradi M. The Effect of Chamomile on Pain and Menstrual Bleeding in Primary Dysmenorrhea: A Systematic Review. International Journal of Community Based Nursing and Midwifery. 2021;9(3):174-186. [https://doi.org/10.30476/ijcbnm.2021.87219.1417]
9. Zaen NL. Effect of Cinnamon (Cinnamomum Burmanni) Aromatherapy on Primary Dysmenorrhea Pain in Students at Air Batu High School in 2021. Science Midwifery. 2021;10(1):417-424. [https://midwifery.iocspublisher.org/index.php/midwifery/article/view/231]
10. Almutairi W, Abunar AA, Alshrif F. Non-Pharmacological Methods to Relieve Dysmenorrhea Among Students of Health Colleges in Saudi Arabia. Novelty Journals. 2020. [https://www.noveltyjournals.com/upload/paper/paperpdf-1608018915.pdf]
11. Hudhariani RN, Yunani AR. The Effect of Massage Effleurage With Lavender Aromatherapy on the Intensity of Dymenorore Pain in Adolescent Women in the Pabelan Health Center. Jurnal Ilmu Dan Teknologi Kesehatan STIKES Widya Husada. 2022;13(2). [https://doi.org/10.33666/jitk.v13i2.450]
12. Dağlı SS, Dağlı R. Pain Relief Effects of Aromatherapy With Rose Oil (Rosa Damascena Mill.) Inhalation in Patients With Primary Dysmenorrhea: A Randomized Controlled Clinical Trial. Journal of Herbal Medicine. 2023;38:100637. [https://doi.org/10.1016/j.hermed.2023.100637]
13. Zayeri F, Dehkordi ZR, Hosseini-Baharanchi FS. The Clinical Efficacy of Lavender Oil Inhalation on Intensity of Menstrual Pain From Primary Dysmenorrhea. Journal of Herbmed Pharmacology. 2019;8(3):218-223. [https://doi.org/10.15171/jhp.2019.32]
14. Nurak MA, Lerik MDC, Tibuludji P, Muntasir M, Muntasir M. Effectiveness of Lavender (Lavandula Angustifolia) and Jasmine (Jasminum Officinale) Aromatherapy on the Intensity of Dysmenorrhea in Student of Faculty of Public Health, Universitas Nusa Cendana, Kupang. International Journal of Pharma Medicine and Biological Sciences. 2020. [https://www.cabidigitallibrary.org/doi/pdf/10.5555/20203596353]
15. Mannucci C, Calapai F, Cardia L, Inferrera G, D'Arena G, Di Pietro M, et al. Clinical Pharmacology of Citrus Aurantium and Citrus Sinensis for the Treatment of Anxiety. Evidence-Based Complementary and Alternative Medicine. 2018;2018:3624094. [https://doi.org/10.1155/2018/3624094] [PMID]
16. González-Mas MC, Rambla JL, López-Gresa MP, Blázquez MA, Granell A. Volatile Compounds in Citrus Essential Oils: A Comprehensive Review. Frontiers in Plant Science. 2019;10:12. [https://doi.org/10.3389/fpls.2019.00012] [PMID]
17. Heydari N, Abootalebi M, Jamalimoghadam N, Kasraeian M, Emamghoreishi M, Akbarzadeh M. Investigation of the Effect of Aromatherapy With Citrus Aurantium Blossom Essential Oil on Premenstrual Syndrome in University Students: A Clinical Trial Study. Complementary Therapies in Clinical Practice. 2018;32:1-5. [https://doi.org/10.1016/j.ctcp.2018.04.006] [PMID]
18. Suntar I, Khan H, Patel S, Celano R, Rastrelli L. An Overview on Citrus Aurantium L.: Its Functions as Food Ingredient and Therapeutic Agent. Oxidative Medicine and Cellular Longevity. 2018;2018:7864269. [https://doi.org/10.1155/2018/7864269] [PMID]
19. Namazi M, Akbari SAA, Mojab F, Talebi A, Majd HA, Jannesari S. Effects of Citrus Aurantium (Bitter Orange) on the Severity of First-Stage Labor Pain. Iranian Journal of Pharmaceutical Research. 2014;13(3):1011-1018. [https://pubmed.ncbi.nlm.nih.gov/25276203/]
20. Namazi M, Akbari SAA, Mojab F, Talebi A, Majd HA, Jannesari S. Aromatherapy With Citrus Aurantium Oil and Anxiety During the First Stage of Labor. Iranian Red Crescent Medical Journal. 2014;16(6):e18371. [https://doi.org/10.5812/ircmj.18371] [PMID]
21. Khodabakhsh P, Shafaroodi H, Asgarpanah J. Analgesic and Anti-Inflammatory Activities of Citrus Aurantium L. Blossoms Essential Oil (Neroli): Involvement of the Nitric Oxide/Cyclic-Guanosine Monophosphate Pathway. Journal of Natural Medicines. 2015;69(3):324-331. [https://doi.org/10.1007/s11418-015-0896-6] [PMID]
22. Williamson A, Hoggart B. Pain: A Review of Three Commonly Used Pain Rating Scales. Journal of Clinical Nursing. 2005;14(7):798-804. [https://doi.org/10.1111/j.1365-2702.2005.01121.x] [PMID]
23. Seyyed-Rasooli A, Salehi F, Mohammadpoorasl A, Goljaryan S, Seyyedi Z, Thomson B. Comparing the Effects of Aromatherapy Massage and Inhalation Aromatherapy on Anxiety and Pain in Burn Patients: A Single-Blind Randomized Clinical Trial. Burns. 2016;42(8):1774-1780. [https://doi.org/10.1016/j.burns.2016.06.014] [PMID]
24. Hamranani SST, Permatasari D. Lavender Aromatherapy on Alleviating Menstrual Pain in Female Teenagers: A Case Study on Polanharjo Klaten. Proceedings of the International Conference on Applied Science and Health. 2019. [https://doi.org/10.5220/0009123301040109]
25. Mohammadi F, Moradi M, Niazi A, Jamali J. The Impact of Aromatherapy With Citrus Aurantium Essential Oil on Sleep Quality in Pregnant Women With Sleep Disorders: A Randomized Controlled Clinical Trial. International Journal of Community Based Nursing and Midwifery. 2022;10(3):160-169. [https://doi.org/10.30476/ijcbnm.2022.92696.1900]
26. Bargi S, Bahraminejad N, Jafari S, Fallah R. The Effect of Aromatherapy With Citrus Aurantium Aroma on Pain After Orthopedic Surgery: A Randomized Clinical Trial. Journal of Caring Sciences. 2023;12(2):116-121. [https://doi.org/10.34172/jcs.2023.30120] [PMID]
27. Sharifipour F, Mirmohammad Ali M, Hashemzadeh M. Comparison of the Effect of Citrus Arantium and Salvia Officinalis Aroma on Post-Cesarean Section Pain. The Iranian Journal of Obstetrics, Gynecology and Infertility. 2017;20(2):41-49. [https://ijogi.mums.ac.ir/article_1100.html]
28. Park H, Seol GH, Ryu S, Choi IY. Neuroprotective Effects of (−)-Linalool Against Oxygen-Glucose Deprivation-Induced Neuronal Injury. Archives of Pharmacal Research. 2016;39(4):555-564. [https://doi.org/10.1007/s12272-016-0714-z] [PMID]
29. Moradi M, Niazi A, Payandar FM, Jamali J, Arefadib N. The Effect of Aromatherapy With Citrus Aurantium Essential Oil on Depression, Stress and Anxiety in Pregnant Women; a Randomized Controlled Clinical Trial. Taiwanese Journal of Obstetrics and Gynecology. 2025;64(3):512-518. [https://doi.org/10.1016/j.tjog.2024.10.020] [PMID]
30. Hutapea LM. Massage and Inhalation Aromatherapy as Alternative Medicine in Pain Management of Primary Dysmenorrhea. Journal of International Scholars Conference-ALLIED HEALTH. 2016. [https://jurnal.unai.edu/index.php/jiscah/article/view/371]
31. Aboualsoltani F, Bastani P, Khodaie L, Fazljou SMB, Salehi-Pourmehr H. The Effect of Citrus Aurantium L. Flower Extract on the Severity of Primary Dysmenorrhoea: A Double-Blind, Randomised, Controlled Clinical Trial. Journal of Herbal Medicine. 2024;45:100878. [https://doi.org/10.1016/j.hermed.2024.100878]

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