Shirin Mozayyan, Ali Mellati, Habib Nazem, Hosein Salavati, Hosein Chiti,
Volume 6, Issue 4 (3-2017)
Abstract
Background: Some patients with GDM (Gestational Diabetes Mellitus) still experience impaired glucose tolerance after childbirth and will be affected by diabetes mellitus type 2.
Objectives: The aim of this study is to investigate the relationship between hs-CRP serum levels with insulin resistance six weeks after childbirth in patients with gestational diabetes mellitus type 2.
Methods: In this descriptive cross-sectional study, 110 patients with GDM were evaluated in terms of the insulin resistance index (HOMA), hs-CRP serum, and the oral glucose tolerance test (OGTT) six weeks after childbirth. Their anthropometric indices were measured in the early pregnancy. Spearman’s rank correlation coefficient and linear regression analysis were used to analyze data in SPSS 16.
Results: The mean of hs-CRP was 8.72 µg/ml among the patients in this study. It is higher than the normal range. Moreover, 24.5% of the patients were suffering from impaired glucose tolerance, and hs-CRP levels were higher than the normal range in 92.6% of these patients. Furthermore, 41.8% of patients showed insulin resistance, and hs-CRP levels were high among 73.9% of them. After age adjustment, the increase in hs-CRP serum level was significantly correlated with insulin resistance (HOMA) and the one-hour and two-hour OGTTs (p=0.007 and p<0.001, respectively).
Conclusion: It appears that age adjustment can help us figure out the relationship between the increase in hs-CRP serum and insulin resistance in pregnant mothers with diabetes six weeks after childbirth.
Fatemeh Bayat, Mina Mousavi, Zahra Moradi, Mahnaz Keshavarz Afshar, Hadis Shahrahmani, Parvin Mohebbi,
Volume 9, Issue 4 (1-2020)
Abstract
Background: Gestational diabetes is one of the most common complications of pregnancy that has several effects on mother and baby.
Objectives: The aim of this study was to examine the prevalence as well as maternal and neonatal outcomes in women with gestational diabetes.
Methods: This descriptive comparative study was carried out on all pregnant women who underwent 75 g glucose test and referred to Ayatollah Mousavi Hospital in Zanjan for delivery from September to March 2018. Data was collected according to the client's biography obtained by the gynecologist and also the available evidence of gestational diabetes. Data was analyzed by SPSS 25 software.
Results: The prevalence of gestational diabetes in the present study was 4.7%. The mean age in the group with gestational diabetes was 30.65± 6.9 years, which was statistically significant compared to the mean age of healthy mothers (27.93± 6.4) (P= 0.01). There was a statistically significant difference in the type of delivery between the two groups (P<0.001) as the delivery method was cesarean section in 70.6% of patients with gestational diabetes. Evaluation of pregnancy and neonatal outcomes between the two groups in terms of the need for induction (15.8% vs. 47.4%), cases of episiotomy (22.8% vs. 43.9%), cesarean delivery (63.2% vs. 26.3%) and the need for hospitalization of the infant in NICU (26.3% vs. 7%) indicated a statistically significant difference (P= 0.01).
Conclusion: This study did not result in a significant difference in maternal and neonatal complications, except for the need for NICU hospitalization and delivery.
Nasibeh Bolghanabadi, Roghieh Kharaghani, Azadeh Hosseinkhani, Sanaz Fayazi, Raziyeh Mossayebnezhad,
Volume 13, Issue 1 (3-2023)
Abstract
Background: Gestational diabetes mellitus (GDM) is the most common complication of pregnancy and an important public health concern. Several studies have investigated the prevalence of gestational diabetes in different parts of Iran with different results.
Objectives: The present study aimed to review studies on gestational diabetes prevalence and estimate the prevalence of gestational diabetes in Iran.
Methods: A search on gestational diabetes mellitus and related synonyms was conducted using global and national databases, including PubMed, Science Direct, Scopus, Web of Sciences, Google Scholar, SID, IranMedex, Magiran, Irandoc, Medlib. Moreover, gray literature and reference checks and a library search were conducted. Keywords included: prevalence, Iran, gestational diabetes mellitus (GDM), and their synonyms. The inclusion criteria were observational studies (cross-sectional, prospective cohorts, and retrospective cohorts) published in Persian or English between 2000 and 2020 on the prevalence or incidence of gestational diabetes in Iran, a sample size of more than 100 people, and availably of full texts. The selected articles were thoroughly reviewed, and after quality assessment, the required information was extracted and included in the meta-analysis.
Results: From 907 articles, 48 were included in the meta-analysis according to the inclusion criteria, which included 51,259 patients with an average age (standard deviation) of 27.05 years (1.83). The overall prevalence of GDM in Iran was 10% (11,9: 95% confidence interval). The prevalence of GDM had increased in recent years, from 4% before 2005 to 16% in 2016 to 2020 (20,12: 95% CI). There was significant heterogeneity between studies, and the I-square index was 98%.
Conclusion: The prevalence of gestational diabetes in Iran is slowly increasing. The increasing prevalence of gestational diabetes can seriously threaten the health of mothers, fetuses, and newborns in the near future.
