Volume 8, Issue 1 (6-2018)                   PCNM 2018, 8(1): 28-35 | Back to browse issues page

XML Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Faghani Aghoozi M, Tehranian N, Amerian M, Fayazi S, Ramezani Tehrani F, Hamta A et al . The Predictive Role of Serum Leptin Levels in Pregnant Mothers in Relation to their Delivery Type. PCNM 2018; 8 (1) :28-35
URL: http://nmcjournal.zums.ac.ir/article-1-569-en.html
The Predictive Role of Serum Leptin Levels in Pregnant Mothers in Relation to their Delivery Type
Marzieh Faghani Aghoozi , Najmeh Tehranian * , Malihe Amerian , Sanaz Fayazi , Fahimeh Ramezani Tehrani , Amir Hamta , Shahrbanoo Salehin
Department of Midwifery and Reproductive Health, Medical Sciences Faculty, Tarbiat Modares University, Tehran, I.R.Iran , n_tehranian@yahoo.com
Abstract:   (12105 Views)

Background: It seems that in vaginal delivery, serum leptin level increases as a cortisol-dependent factor due to the stress of the embryo. Studies have shown that if the level of serum leptin is low, the risk of chronic metabolic diseases, cardiovascular diseases, hypertension, and obesity in the mother and the baby will increase.
Objectives: The aim of this study was to determine the relationship between serum leptin levels in pregnancy and the type of delivery.
Methods: This study was a descriptive-analytic study which adopted a longitudinal approach to examine 45 mothers in the first and second trimester of pregnancy in Tehran in 2015. The participants were selected by means of cluster random sampling. After obtaining consent from the mothers, their blood samples were collected at 6-12 and 15-20 weeks of pregnancy and their serum leptin levels were determined. The mothers’ examination continued after their delivery. Finally, the mothers were divided into two groups including the vaginal delivery group (24 participants) and the cesarean group (21 participants). Independent-Samples t-test, Pearson test, regression test, and Lambda test were used to analyze the data. SPSS was employed to carry out analyses at P value<0/05 level.
Results: The mean values of the serum leptin level in the first trimester and second trimester were higher in the normal delivery group in comparison with the cesarean group. Nonetheless, there was not a significant relationship between the serum leptin level and the type of delivery despite the fact that there was a statistically significant relationship between the type of delivery and the changes in leptin levels during pregnancy and these changes were reported more frequently in the normal delivery group in comparison with in the cesarean group (P value=0.021).
Conclusion: Based on the results of this study, leptin level changes during pregnancy can have a predictive role in the mothers’ type of delivery. However, further studies with larger samples are required to confirm the extent and type of this role.

Keywords: leptin, pregnancy, type of delivery
Full-Text [PDF 612 kb]   (11626 Downloads)    
Type of Study: Orginal research | Subject: Nursing
Received: 2019/02/24 | Accepted: 2018/06/15 | Published: 2018/06/15
References
1. Aghoozi MF, Tehranian N. Effect of Leptin on weight gain in pregnant women: A systematic review. Iran J Obstet Gynecol Infertil. 2015; 17(132): 16-27. [In Persian]
2. Hajagos-Tóth J, Ducza E, Samavati R, Vari S, Gaspar R. Obesity in pregnancy: a novel concept on the roles of adipokines in uterine contractility. Croat Med J. 2017; 58(2): 96-104. [Crossref]
3. Gustavsson C, Hall UA, Pelanis A, et al. Cerebrospinal fluid levels of insulin, leptin, and agouti-related protein in relation to BMI in pregnant women. Obesity (Silver Spring). 2016; 24(6): 1299-304. [Crossref]
4. Farias D, Poston L, Franco-Sena A, et al. Maternal lipids and leptin concentrations are associated with large-for-gestational-age births: a prospective cohort study. Sci Rep. 2017; 7(1): 804. [Crossref]
5. Nuamah M, Yura S, Sagawa N, et al. Significant increase in maternal plasma leptin concentration in induced delivery: a possible contribution of pro-inflammatory cytokines to placental leptin secretion. Endocr J. 2004; 51(2): 177-87. [Crossref]
6. Rytlewski K, Huras H, Kuśmierska-Urban K, ałaś G, Reroń A. Leptin and interferon-gamma as possible predictors of cesarean section among women with hypertensive disorders of pregnancy. Med Sci Monit. 2012; 18(8): 506-11. [Crossref]
7. Haghiac M, Basu S, Presley L, Serre D, Catalano PM, Mouzon SH-d. Patterns of Adiponectin Expression in Term Pregnancy: Impact of Obesity. J Clin Endocrinol Metab. 2014; 99(9): 3427-34. [Crossref]
8. Tsai P, Davis J, Bryant-Greenwood G. Systemic and placental leptin and its receptors in pregnancies associated with obesity. Reprod Sci. 2015; 22(2): 189-97. [Crossref]
9. Fakor F, Sharami S, Milani F, et al. The association between level of maternal serum leptin in the third trimester and the occurrence of moderate preterm labor. J Turk Ger Gynecol Assoc. 2016; 17(4): 182-85. [Crossref]
10. Hajimirzaie S, Samkan Z, Tehranian N. Comparison of Maternal Serum Leptin Levels During the Third Trimester of Pregnancy and Postpartum in the Two Groups of Vaginal Delivery and Caesarean Section. Indian J Endocr Metab. 2015; 17(4): 274-81. [In Persian]
11. Pérez-Pérez A, Toro A, Vilariño-García T, et al. Leptin action in normal and pathological pregnancies. J Cell Mol Med. 2018; 22(2): 716-27.
12. Page-Wilson G, Reitman-Ivashkov E, Meece K, et al. Cerebrospinal fluid levels of leptin, proopiomelanocortin, and agouti-related protein in human pregnancy: evidence for leptin resistance. J Clin Endocrinol Metab. 2013; 98(1): 264-71. [Crossref]
13. Brocato B, Zoerner A, Janjetovic Z, et al. Endocannabinoid crosstalk between placenta and maternal fat in a baboon model (Papio spp.) of obesity. Placenta. 2013; 34(11): 983-89. [Crossref]
14. Piya M, Harte A, Sivakumar K, et al. The identification of irisin in human cerebrospinal fluid: influence of adiposity, metabolic markers, and gestational diabetes. Am J Physiol Endocrinol Metab. 2014; 306(5): 512-18. [Crossref]
15. Aye I, Lager S, Ramirez V, et al. Increasing maternal body mass index is associated with systemic inflammation in the mother and the activation of distinct placental inflammatory pathways. Biol Reprod. 2014; 90(6): 129. [Crossref]
16. Martino J, Sebert S, Segura MT, et al. Maternal Body Weight and Gestational Diabetes Differentially Influence Placental and Pregnancy Outcomes. J Clin Endocrinol Metab. 2016; 101(1): 59-68. [Crossref]
17. Kominiarek M, Gambala C, Sutherland M, Varady K. Adipokinins in pregnancies at risk of preterm delivery. Gynecol Endocrinol. 2016; 32(1): 78-81. [Crossref]
18. Bozkurt L, Göbl C, Baumgartner-Parzer S, Luger A, Pacini G, Kautzky-Willer A. Adiponectin and Leptin at Early Pregnancy: Association to Actual Glucose Disposal and Risk for GDM-A Prospective Cohort Study. Int J Endocrinol. 2018: 1-8. [Crossref]
19. Ghesquiere L, Hanssens S, Leroy A, Petit C, Deruelle P, Azais H. Sport: A key element for myometrial contractility and regulation of adipokines in obese pregnant women? Gynecol Obstet Fertil Senol. 2018; 46(7-8): 587-92. [Crossref]
20. Sámano R, Martínez-Rojano H, Chico-Barba G, et al. Serum Concentration of Leptin in Pregnant Adolescents Correlated with Gestational Weight Gain, Postpartum Weight Retention and Newborn Weight/Length. Nutrients. 2017; 9(10): 1-16. [Crossref]
21. Newcomer JW, Selke G, Melson AK, Gross J, Vogler GP, Dagogo-Jack S. Dose-dependent cortisol-induced increases in plasma leptin concentration in healthy humans. Arch Gen psychiatry. 1998; 55(11): 995-1000. [Crossref]
22. Ortega-Senovilla H, Schaefer-Graf U, Meitzner K, Graf K, Abou-Dakn M, Herrera E. Lack of relationship between cord serum angiopoietin-like protein 4 (ANGPTL4) and lipolytic activity in human neonates born by spontaneous delivery. PLoS One. 2013; 8(12): e81201. [Crossref]
23. Farid S, Najati N, Gharebaghi M, Haghjo A, Ghojazadeh M. Resistin in cord blood of small for gestation age and appropriate for gestation age term neonates. Iran J Pediatr. 2013; 23(6): 659-63.
24. Logan C, Thiel L, Bornemann R, et al. Delivery Mode, Duration of Labor, and Cord Blood Adiponectin, Leptin, and C-Reactive Protein: Results of the Population-Based Ulm Birth Cohort Studies. PLoS One. 2016; 11(2): 1-16. [Crossref]
25. Kim KH, Kim YJ, Lee S, et.al. Evaluation of plasma leptin levels & BMI as predictor of postpartum weight retention. Indian J Med Res. 2008; 128(5): 595-600.
26. Castellano Filho DS, do Amaral Correa JO, Dos Santos Ramos P, et al. Body weight gain and serum leptin levels of non-overweight and overweight/obese pregnant women. Med Sci Monit. 2013; 19: 1043-49. [Crossref]
27. Nunes M, Silva Cd, Bosa V, Bernardi J, Werlang I, Goldani M. Could a remarkable decrease in leptin and insulin levels from colostrum to mature milk contribute to early growth catch-up of SGA infants? BMC Pregnancy Childbirth. 2017; 17(1): 410. [Crossref]
28. Hermansson H, Hoppu U, Isolauri E. Elective Caesarean Section Is Associated with Low Adiponectin Levels in Cord Blood. Neonatology. 2014; 105(3): 172-74. [Crossref]
29. Yoshimitsu N, Douchi T, Kamio M, Nagata Y. Differences in umbilical venous and arterial leptin levels by mode of delivery. Obste Gynecol. 2000; 96(3): 342-45. [Crossref]
30. Perng W, Rifas-Shiman S, McCulloch S, et al. Associations of cord blood metabolites with perinatal characteristics, newborn anthropometry, and cord blood hormones in project viva. Metabolism. 2017; 76: 11-22. [Crossref]
31. Cunningham F, Leveno J, Bloom L, Hauth C, Rose J, Spong Y. Williams Obstetrics. 24th ed. New York: McGraw-Hill; 2014.
32. Hajimirzaie S, Samkan Z, Tehranian N. The effects of leptin on pregnancy and neonatal outcome, A Review. J Urmia Nurs Midwifery Fac. 2015; 13(8): 699-717. [In Persian].
Add your comments about this article : Your username or Email:
CAPTCHA
Send email to the article author

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

© 2025 CC BY-NC 4.0 | Preventive Care in Nursing & Midwifery Journal

Designed & Developed by : Yektaweb